The two major airports that service Niles are the O'Hare International Airport which is eight miles from Niles (and offers direct flights to more cities than any other airport in the world), and the Midway International Airport, which is located 18 miles south of Niles.

As another alternative, just nine miles away is the Chicago Executive Airport, which is a regional airport accommodating private and corporate aircraft.

There are two railroad lines that provide commuter service to Chicago with express trains reaching the loop in less than 25 minutes. They are Metra’s Milwaukee District North Line and the Union Pacific District Northwest Line. One may also reach Chicago Transit Authority (CTA) Blue and Yellow Lines (Chicago's "L") via public bus routes and Regional Transportation Authority (RTA).

The Pace Bus System services the local area and further facilitates travel from Niles to Chicago via rapid transit. Pace also provides Niles commuters with daily transportation to other neighboring communities. As an added convenience, village residents enjoy a free intra-community bus system known as the Niles Free Bus.

Major Roadways
Major north-south roadways include:
  • State Route 21 (Milwaukee Avenue)
  • State Route 43 (Harlem Avenue)
  • Caldwell Avenue
Major east-west roadways include:
  • State Route 58 (Golf Road)
  • State Route 14 (Dempster Avenue)
  • Oakton Street
  • Touhy Avenue

Interstate Highways

Interstate highways are just minutes away from Niles. Those interstates include:
  • I-94 (Edens Expressway) to the east
  • I-90 (Kennedy Expressway) to the south
  • I-294 (Tri-State Tollway) to the west